The natural history of ubiquitin and ubiquitin-related domains.
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ABSTRACT:
SUBMITTER: Burroughs AM
PROVIDER: S-EPMC5881585 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
The natural history of ubiquitin and ubiquitin-related domains.
Burroughs Alexander Maxwell AM Iyer Lakshminarayan M LM Aravind L L
Frontiers in bioscience (Landmark edition) 20120101 4
The ubiquitin (Ub) system is centered on conjugation and deconjugation of Ub and Ub-like (Ubls) proteins by a system of ligases and peptidases, respectively. Ub/Ubls contain the beta-grasp fold, also found in numerous proteins with biochemically distinct roles unrelated to the conventional Ub-system. The beta-GF underwent an early radiation spawning at least seven clades prior to the divergence of extant organisms from their last universal common ancestor, first emerging in the context of transl ...[more]
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