Searching for neurodegeneration in multiple sclerosis at clinical onset: Diagnostic value of biomarkers.

ABSTRACT:

Background

Neurodegeneration occurs during the early stages of multiple sclerosis. It is an essential, devastating part of the pathophysiology. Tools for measuring the degree of neurodegeneration could improve diagnostics and patient characterization.

Objective

This study aimed to determine the diagnostic value of biomarkers of degeneration in patients with recent clinical onset of suspected multiple sclerosis, and to evaluate these biomarkers for characterizing disease course.

Methods

This cross-sectional study included 271 patients with clinical features of suspected multiple sclerosis onset and was the baseline of a prospective study. After diagnostic investigations, the patients were classified into the following disease groups: patients with clinically isolated s

SUBMITTER: Novakova L 

PROVIDER: S-EPMC5882126 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature