Ontology highlight
ABSTRACT:
SUBMITTER: Tjhin ET
PROVIDER: S-EPMC5882169 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Tjhin Erick T ET Spry Christina C Sewell Alan L AL Hoegl Annabelle A Barnard Leanne L Sexton Anna E AE Siddiqui Ghizal G Howieson Vanessa M VM Maier Alexander G AG Creek Darren J DJ Strauss Erick E Marquez Rodolfo R Auclair Karine K Saliba Kevin J KJ
PLoS pathogens 20180403 4
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antiplasmodial pantothenate analogues, including pantothenol and CJ-15,801, kill the parasite by targeting CoA biosynthesis/utilisation. Their mechanism of action, however, remains unknown. Here, we show that parasites pressured with pantothenol or CJ-15,8 ...[more]