Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes.

ABSTRACT: Reports of the role of host interleukin 28B (IL-28B) genetic variants in liver disease severity in patients with chronic hepatitis C (CHC) have obtained conflicting results. The impact of IL-28B in Asian patients with different viral genotypes remains elusive.We try to elucidate the effect of IL-28B genetic variants in a large Asian cohort with different viral genotypes.The association between the IL-28B rs8099917 genotype and liver fibrosis was investigated in 1288 patients with biopsy-proven CHC.Patients with hepatitis C virus genotype 1 (HCV-1) infection comprised 59.4% of the population. The remaining 40.6% (518 patients) did not have HCV-1 infection. Of the 1084 patients with the IL-28 genotype, 85.6% (928 patients) had the TT genotype. Univariate analysis revealed that, compared to patients without advanced liver fibrosis, patients with advanced liver fibrosis (Metavir fibrosis score 3-4) had an older age, a lower platelet count, a higher ?-fetoprotein level, a higher alanine aminotransferase level, a higher incidence of diabetes, and a higher frequency of rs8099917 non-TT genotype carriage.Logistic regression analysis revealed that factors significantly associated with advanced liver fibrosis included age (odds ratio [OR]/95% confidence interval [CI]: 1.023/1.009-1.037, P?=?.001), diabetes (OR/CI: 1.736/1.187-2.539, P?=?.004), ?-fetoprotein (OR/CI: 1.007/1.002-1.012, P?=?.009), platelet count (OR/CI: 0.991/0.988-0.993, P?

SUBMITTER: Huang CI 

PROVIDER: S-EPMC5882450 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature