MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein α.

ABSTRACT:

Background

Signal-regulatory protein α (SIRPα) is an essential signaling molecule that modulates leukocyte inflammatory responses. However, the regulation of selective SIRPα synthesis and its dynamic changes in leukocytes under inflammatory stimulation remain incompletely understood.

Objective

We sought to identify the microRNAs (miRNAs) that posttranscriptionally regulate SIRPα synthesis and their roles in modulating macrophage inflammatory responses.

Methods

SIRPα was induced in SIRPα-negative promyelocytic cells by retinoic acid or phorbol 12-myristate 13-acetate, and the differential expression of miRNAs was assessed by means of microarray and quantitative RT-PCR assays. The roles of identified miRNAs in controlling SIRPα synthesis in leukocytes and leukocyte infl

SUBMITTER: Zhu D 

PROVIDER: S-EPMC5882493 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature