Ontology highlight
ABSTRACT:
SUBMITTER: Klecka M
PROVIDER: S-EPMC5883037 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Klecka Martin M Thybo Christina C Macaubas Claudia C Solov'yov Ilia I Simard Julia J Balboni Imelda Maria IM Fox Emily E Voss Anne A Mellins Elizabeth D ED Astakhova Kira K
Scientific reports 20180403 1
Autoantibodies to nuclear components of cells (antinuclear antibodies, ANA), including DNA (a-DNA), are widely used in the diagnosis and subtyping of certain autoimmune diseases, including systemic lupus erythematosus (SLE). Despite clinical use over decades, precise, reproducible measurement of a-DNA titers remains difficult, likely due to the substantial sequence and length heterogeneity of DNA purified from natural sources. We designed and tested a panel of synthetic nucleic acid molecules co ...[more]