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Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation.

ABSTRACT: An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73?mg/mg, BSA/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well.

SUBMITTER: Kong W

PROVIDER: S-EPMC5883060 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation.

Kong Weifu W Wan Jiaxun J Namuangruk Supawadee S Guo Jia J Wang Changchun C

Scientific reports 20180403 1

An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSA/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well. ...[more]

PMID: 29615680

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