Browse
Submit Data
Databases
API
Help

Dataset Information

5 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation.

ABSTRACT: An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73?mg/mg, BSA/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well.

SUBMITTER: Kong W

PROVIDER: S-EPMC5883060 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation.

Kong Weifu W Wan Jiaxun J Namuangruk Supawadee S Guo Jia J Wang Changchun C

Scientific reports 20180403 1

An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSA/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well. ...[more]

PMID: 29615680

Similar Datasets

Constructing covalent organic frameworks in water <i>via</i> dynamic covalent bonding.

Project description:The formation of keto-enamine based crystalline, porous polymers in water is investigated for the first time. Facile access to the Schiff base reaction in water has been exploited to synthesize stable porous structures using the principles of Dynamic Covalent Chemistry (DCC). Most credibly, the water-based Covalent Organic Frameworks (COFs) possess chemical as well as physical properties such as crystallinity, surface area and porosity, which is comparable to their solvothermal counterparts. The formation of COFs in water is further investigated by understanding the nature of the monomers formed using hydroxy and non-hydroxy analogues of the aldehyde. This synthetic route paves a new way to synthesize COFs using a viable, greener route by utilization of the DCC principles in conjunction with the keto-enol tautomerism to synthesize useful, stable and porous COFs in water.

| S-EPMC5094442 | biostudies-literature

A highly soluble, crystalline covalent organic framework compatible with device implementation.

Project description:Covalent organic frameworks (COFs) have emerged as a tailor-made platform for designing next-generation two-dimensional materials. However, COFs are produced as insoluble and unprocessable solids, which precludes the preparation of thin films for optoelectronic applications. Here, we report designed synthesis of a highly soluble yet crystalline COF material through the regulation of its inter-layer interactions. The resulting COF is remarkably soluble in a variety of organic solvents and forms stable true solutions with retention of its layered structure. These unique features endow the COF with solution processability; high-quality, large-area COF films can be produced on various substrates in a high-throughput and efficient manner, with good control over the film thickness, making this material compatible with a variety of device applications. The films are electrically anisotropic; the intra-layer carrier conduction is inhibited, while the inter-layer carrier migration is outstanding, showing the highest conductivity among all reported COF materials. Our highly soluble and processable COF may open new pathways for realising high-performance COF-based optoelectronic devices with diverse functions.

| S-EPMC6346726 | biostudies-literature

Water cluster in hydrophobic crystalline porous covalent organic frameworks.

Project description:Progress over the past decades in water confinement has generated a variety of polymers and porous materials. However, most studies are based on a preconception that small hydrophobic pores eventually repulse water molecules, which precludes the exploration of hydrophobic microporous materials for water confinement. Here, we demonstrate water confinement across hydrophobic microporous channels in crystalline covalent organic frameworks. The frameworks are designed to constitute dense, aligned and one-dimensional polygonal channels that are open and accessible to water molecules. The hydrophobic microporous frameworks achieve full occupation of pores by water via synergistic nucleation and capillary condensation and deliver quick water exchange at low pressures. Water confinement experiments with large-pore frameworks pinpoint thresholds of pore size where confinement becomes dominated by high uptake pressure and large exchange hysteresis. Our results reveal a platform based on microporous hydrophobic covalent organic frameworks for water confinement.

| S-EPMC8604923 | biostudies-literature

Charge-Enhanced Separation of Organic Pollutants in Water by Anionic Covalent Organic Frameworks.

Project description:The effective removal of organic pollutants in wastewater is a key environmental challenge. In this work, an anionic covalent organic framework (named TpPa-SO3Na) was synthesized through a green two-in-one synthesis strategy with autocatalytic imine formation. The slowly generated acetic acid as a catalyst is favorable to sustain the reversibility of the covalent organic framework (COF) formation reaction and improve the crystallinity of TpPa-SO3Na. TpPa-SO3Na consists of a homogeneous distribution of sulfonate groups to produce negatively charged regular channels. The strong electrostatic and hydrogen-bonding interactions between the sulfonate groups anchored in the nanochannels and the amine groups in organic pollutants improve the adsorption selectivity and capacity. These structures allow a high degree of control over adsorption processes to boost the adsorption kinetics and improve selective separation. TpPa-SO3Na exhibits ultrafast adsorption (<1 min) of cationic antibiotics and dyes (average over 95%). Furthermore, TpPa-SO3Na exhibits high selectivity for the uptake of dye molecules on the basis of the differences in charge and molecular size. This work explored functional designs and green manufacturing of anionic COFs for removal of hydrophilic organic pollutants.

| S-EPMC7745399 | biostudies-literature

Fluorescent water-soluble organic aerosols in the High Arctic atmosphere.

Project description:Organic aerosols are ubiquitous in the earth's atmosphere. They have been extensively studied in urban, rural and marine environments. However, little is known about the fluorescence properties of water-soluble organic carbon (WSOC) or their transport to and distribution in the polar regions. Here, we present evidence that fluorescent WSOC is a substantial component of High Arctic aerosols. The ratios of fluorescence intensity of protein-like peak to humic-like peak generally increased from dark winter to early summer, indicating an enhanced contribution of protein-like organics from the ocean to Arctic aerosols after the polar sunrise. Such a seasonal pattern is in agreement with an increase of stable carbon isotope ratios of total carbon (δCTC) from -26.8‰ to -22.5‰. Our results suggest that Arctic aerosols are derived from a combination of the long-range transport of terrestrial organics and local sea-to-air emission of marine organics, with an estimated contribution from the latter of 8.7-77% (mean 45%).

| S-EPMC4412076 | biostudies-other

Singlet oxygen generation from water-soluble quantum dot-organic dye nanocomposites.

Project description:Water-soluble quantum dot-organic dye nanocomposites have been prepared via electrostatic interaction. We used CdTe quantum dots with diameters up to 3.4 nm, 2-aminoethanethiol as a stabilizer, and meso-tetra(4-sulfonatophenyl)porphine dihydrochloride (TSPP) as an organic dye. The photophysical properties of the nanocomposite have been investigated. The fluorescence of the parent CdTe quantum dot is largely suppressed. Instead, indirect excitation of the TSPP moiety leads to production of singlet oxygen with a quantum yield of 0.43. The nanocomposite is sufficiently photostable for biological applications.

| S-EPMC3164884 | biostudies-literature

Oriented Films of Conjugated 2D Covalent Organic Frameworks as Photocathodes for Water Splitting.

Project description:Light-driven water electrolysis at a semiconductor surface is a promising way to generate hydrogen from sustainable energy sources, but its efficiency is limited by the performance of available photoabsorbers. Here we report the first time investigation of covalent organic frameworks (COFs) as a new class of photoelectrodes. The presented 2D-COF structure is assembled from aromatic amine-functionalized tetraphenylethylene and thiophene-based dialdehyde building blocks to form conjugated polyimine sheets, which ?-stack in the third dimension to create photoactive porous frameworks. Highly oriented COF films absorb light in the visible range to generate photoexcited electrons that diffuse to the surface and are transferred to the electrolyte, resulting in proton reduction and hydrogen evolution. The observed photoelectrochemical activity of the 2D-COF films and their photocorrosion stability in water pave the way for a novel class of photoabsorber materials with versatile optical and electronic properties that are tunable through the selection of appropriate building blocks and their three-dimensional stacking.

| S-EPMC6400428 | biostudies-literature

Water-Soluble and Cytocompatible Phospholipid Polymers for Molecular Complexation to Enhance Biomolecule Transportation to Cells in Vitro.

Project description:Water-soluble and cytocompatible polymers were investigated to enhance a transporting efficiency of biomolecules into cells in vitro. The polymers composed of a 2-methacryloyloxyethyl phosphorylcholine (MPC) unit, a hydrophobic monomer unit, and a cationic monomer unit bearing an amino group were synthesized for complexation with model biomolecules, siRNA. The cationic MPC polymer was shown to interact with both siRNA and the cell membrane and was successively transported siRNA into cells. When introducing 20-50 mol% hydrophobic units into the cationic MPC polymer, transport of siRNA into cells. The MPC units (10-20 mol%) in the cationic MPC polymer were able to impart cytocompatibility, while maintaining interaction with siRNA and the cell membrane. The level of gene suppression of the siRNA/MPC polymer complex was evaluated in vitro and it was as the same level as that of a conventional siRNA transfection reagent, whereas its cytotoxicity was significantly lower. We concluded that these cytocompatible MPC polymers may be promising complexation reagent for introducing biomolecules into cells, with the potential to contribute to future fields of biotechnology, such as in vitro evaluation of gene functionality, and the production of engineered cells with biological functions.

| S-EPMC7465638 | biostudies-literature

Dynamics of Residential Water-Soluble Organic Gases: Insights into Sources and Sinks.

Project description:Water-soluble organic gas (WSOG) concentrations are elevated in homes. However, WSOG sources, sinks, and concentration dynamics are poorly understood. We observed substantial variations in 23 residential indoor WSOG concentrations measured in real time in a North Carolina, U.S., home over several days with a high-resolution time-of-flight chemical ionization mass spectrometer equipped with iodide reagent ion chemistry (I-HR-ToF-CIMS). Concentrations of acetic, formic, and lactic acids ranged from 30-130, 15-53, and 2.5-360 ?g m-3, respectively. Concentrations of several WSOGs, including acetic and formic acids, decreased considerably (?30-50%) when the air conditioner (AC) cycled on, suggesting that the AC system is an important sink for indoor WSOGs. In contrast to nonpolar organic gases, indoor WSOG loss rate coefficients were substantial for compounds with high oxygen-to-carbon (O/C) ratios (e.g., 1.6-2.2 h-1 for compounds with O/C > 0.75 when the AC system was off). Loss rate coefficients in the AC system were more uncertain but were estimated to be 1.5 h-1. Elevated concentrations of lactic acid coincided with increased human occupancy and cooking. We report several WSOGs emitted from cooking and cleaning as well as transported in from outdoors. In addition to indoor air chemistry, these results have implications to exposure and human health.

| S-EPMC7279883 | biostudies-literature

A Perspective on the Application of Covalent Organic Frameworks for Detection and Water Treatment.

Project description:Global population growth and water resource scarcity are significant social problems currently being studied by many researchers focusing on finding new materials for water treatment. The aim is to obtain quality water suitable for drinking and industrial consumption. In this sense, an emergent class of crystalline porous materials known as Covalent-Organic Frameworks (COFs) offers a wide range of possibilities since their structures can be designed on demand for specific applications. Indeed, in the last decade, many efforts have been made for their use in water treatment. This perspective article aims to overview the state-of-the-art COFs collecting the most recent results in the field for water detection of pollutants and water treatment. After the introduction, where we overview the classical design strategies on COF design and synthesis for obtaining chemically stable COFs, we summarize the different experimental methodologies used for COFs processing in the form of supported and free-standing membranes and colloids. Finally, we describe the use of COFs in processes involving the detection of pollutants in water and wastewater treatment, such as the capture of organic compounds, heavy metals, and dyes, the degradation of organic pollutants, as well as in desalination processes. Finally, we provide a perspective on the field and the potential technological use of these novel materials.

| S-EPMC8304028 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data