Ontology highlight
ABSTRACT:
SUBMITTER: Lando D
PROVIDER: S-EPMC5883084 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Lando David D Stevens Tim J TJ Basu Srinjan S Laue Ernest D ED
Nucleus (Austin, Tex.) 20180101 1
Single-cell chromosome conformation capture approaches are revealing the extent of cell-to-cell variability in the organization and packaging of genomes. These single-cell methods, unlike their multi-cell counterparts, allow straightforward computation of realistic chromosome conformations that may be compared and combined with other, independent, techniques to study 3D structure. Here we discuss how single-cell Hi-C and subsequent 3D genome structure determination allows comparison with data fr ...[more]