Ontology highlight
ABSTRACT:
SUBMITTER: Hollinshead KER
PROVIDER: S-EPMC5883319 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cell reports 20180301 12
Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic function of the IDH1 R132H enzyme that has received less attention is the perturbation of cellular redox homeostasis. Here, we describe a biosynthetic pathway exhibited by cells expressing mutant IDH1. By virtue of a change in cellular redox homeostasis, IDH ...[more]