Ontology highlight
ABSTRACT:
SUBMITTER: Xiong G
PROVIDER: S-EPMC5883523 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Xiong Guangbing G Huang Hua H Feng Mengyu M Yang Gang G Zheng Suli S You Lei L Zheng Lianfang L Hu Ya Y Zhang Taiping T Zhao Yupei Y
Journal of experimental & clinical cancer research : CR 20180403 1
<h4>Background</h4>By regulating target genes, microRNAs play essential roles in carcinogenesis and drug resistance in human pancreatic ductal adenocarcinoma (PDAC). Previous studies have shown that microRNA-10a-5p (miR-10a-5p) is overexpressed in PDAC and acts as an oncogene to promote the metastatic behavior of PDAC cells. However, the role of miR-10a-5p in PDAC chemoresistance remains unclear.<h4>Methods</h4>The effects of miR-10a-5p on biological behaviors were analyzed. MiR-10a-5p and TFAP2 ...[more]