Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope.

ABSTRACT: The LINC complex is found in a wide variety of organisms and is formed by the transluminal interaction between outer- and inner-nuclear-membrane KASH and SUN proteins, respectively. Most extensively studied are SUN1 and SUN2 proteins, which are widely expressed in mammals. Although SUN1 and SUN2 play functionally redundant roles in several cellular processes, more recent studies have revealed diverse and distinct functions for SUN1. While several recent in vitro structural studies have revealed the molecular details of various fragments of SUN2, no such structural information is available for SUN1. Herein, we conduct a systematic analysis of the molecular relationships between SUN1 and SUN2, highlighting key similarities and differences that could lead to clues into their distinct function

SUBMITTER: Jahed Z 

PROVIDER: S-EPMC5883562 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature