A phylogenetic and evolutionary analysis of antimycin biosynthesis.
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ABSTRACT:
SUBMITTER: Joynt R
PROVIDER: S-EPMC5883857 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
A phylogenetic and evolutionary analysis of antimycin biosynthesis.
Joynt Rebecca R Seipke Ryan F RF
Microbiology (Reading, England) 20171107 1
Streptomyces species and other Actinobacteria are ubiquitous in diverse environments worldwide and are the source of, or inspiration for, the majority of antibiotics. The genomic era has enhanced biosynthetic understanding of these valuable chemical entities and has also provided a window into the diversity and distribution of natural product biosynthetic gene clusters. Antimycin is an inhibitor of mitochondrial cytochrome c reductase and more recently was shown to inhibit Bcl-2/Bcl-XL-related a ...[more]
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