Ontology highlight
ABSTRACT:
SUBMITTER: Fujimura T
PROVIDER: S-EPMC5884646 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Fujimura Taku T Sato Yota Y Tanita Kayo K Kambayashi Yumi Y Otsuka Atsushi A Fujisawa Yasuhiro Y Yoshino Koji K Matsushita Shigeto S Funakoshi Takeru T Hata Hiroo H Yamamoto Yuki Y Uchi Hiroshi H Nonomura Yumi Y Tanaka Ryota R Aoki Megumi M Imafuku Keisuke K Okuhira Hisako H Furudate Sadanori S Hidaka Takanori T Aiba Setsuya S
Oncotarget 20180215 21
Antibodies against PD-1, such as nivolumab and pembrolizumab, are widely used in the treatment of various cancers including advanced melanoma. The anti-PD-1 Ab significantly prolongs survival in patients with metastatic melanoma, and its administration in combination with local or systemic therapy may also lead to improved outcomes. Although anti-PD-1 Ab-based combined therapy might be effective for the treatment of advanced melanoma, the associated risk of irAEs is an important consideration. T ...[more]