Ontology highlight
ABSTRACT:
SUBMITTER: Kautza B
PROVIDER: S-EPMC5884699 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Kautza Benjamin B Gomez Hernando H Escobar Daniel D Corey Catherine C Ataya Bilal B Luciano Jason J Botero Ana Maria AM Gordon Lisa L Brumfield John J Martinez Silvia S Holder Andre A Ogundele Olufunmilayo O Pinsky Michael M Shiva Sruti S Zuckerbraun Brian S BS
Nitric oxide : biology and chemistry 20150926
<h4>Objective</h4>The cellular injury that occurs in the setting of hemorrhagic shock and resuscitation (HS/R) affects all tissue types and can drive altered inflammatory responses. Resuscitative adjuncts hold the promise of decreasing such injury. Here we test the hypothesis that sodium nitrite (NaNO2), delivered as a nebulized solution via an inhalational route, protects against injury and inflammation from HS/R.<h4>Methods</h4>Mice underwent HS/R to a mean arterial pressure (MAP) of 20 or 25 ...[more]