Ontology highlight
ABSTRACT:
SUBMITTER: Yoon HJ
PROVIDER: S-EPMC5884825 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Yoon Hyun Jung HJ Lee Sungmin S Park Sun Joo SJ Wu Sangwook S
Scientific reports 20180404 1
Non-receptor tyrosine kinase c-Src plays a critical role in numerous cellular signalling pathways. Activation of c-Src from its inactive to the active state involves large-scale conformational changes, and is controlled by the phosphorylation state of two major phosphorylation sites, Tyr416 and Tyr527. A detailed mechanism for the entire conformational transition of c-Src via phosphorylation control of Tyr416 and Tyr527 is still elusive. In this study, we investigated the inactive-to-active conf ...[more]