Ontology highlight
ABSTRACT:
SUBMITTER: Hiraike Y
PROVIDER: S-EPMC5885759 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Nature cell biology 20170814 9
Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions. NFIA and the master transcriptional regulator of adipogenesis, PPARγ, co-localize at the brown-fat-specific enhancers. Moreover, the binding of NFIA precedes and facilitates the binding of PPARγ, lead ...[more]