Dataset Information
The vinylogous Catellani reaction: a combined computational and experimental study.
Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto Y
PROVIDER: S-EPMC5885779 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
The vinylogous Catellani reaction: a combined computational and experimental study.
Chemical science 20171130 5
In the presence of 5 mol% Pd(OAc)<sub>2</sub>, 1 equiv. of norbornene, and K<sub>2</sub>CO<sub>3</sub>, the reaction of 4-iodo-2-quinolones with tertiary <i>o</i>-bromobenzylic alcohols produced the desired benzopyran-fused 2-quinolones in moderate to high yields. A Catellani-type mechanism involving vinylic C-H cleavage is proposed based on the results of control experiments and density functional theory calculations. ...[more]