COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression.
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ABSTRACT:
SUBMITTER: Nedeljkovic I
PROVIDER: S-EPMC5886099 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression.
Nedeljkovic Ivana I Lahousse Lies L Carnero-Montoro Elena E Faiz Alen A Vonk Judith M JM de Jong Kim K van der Plaat Diana A DA van Diemen Cleo C CC van den Berge Maarten M Obeidat Ma'en M Bossé Yohan Y Nickle David C DC Consortium B I O S BIOS Uitterlinden Andre G AG van Meurs Joyce B J JBJ Stricker Bruno H C BHC Brusselle Guy G GG Postma Dirkje S DS Boezen H Marike HM van Duijn Cornelia M CM Amin Najaf N
Human molecular genetics 20180101 2
Chronic obstructive pulmonary disease (COPD) is among the major health burdens in adults. While cigarette smoking is the leading risk factor, a growing number of genetic variations have been discovered to influence disease susceptibility. Epigenetic modifications may mediate the response of the genome to smoking and regulate gene expression. Chromosome 19q13.2 region is associated with both smoking and COPD, yet its functional role is unclear. Our study aimed to determine whether rs7937 (RAB4B, ...[more]
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