Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer.
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ABSTRACT:
SUBMITTER: Remsik J
PROVIDER: S-EPMC5886127 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer.
Remšík Ján J Fedr Radek R Navrátil Jiří J Binó Lucia L Slabáková Eva E Fabian Pavel P Svoboda Marek M Souček Karel K
British journal of cancer 20180220 6
Background:The intratumoural heterogeneity, often driven by epithelial-to-mesenchymal transition (EMT), significantly contributes to chemoresistance and disease progression in adenocarcinomas. Methods:We introduced a high-throughput screening platform to identify surface antigens that associate with epithelial–mesenchymal plasticity in well-defined pairs of epithelial cell lines and their mesenchymal counterparts. Using multicolour flow cytometry, we then analysed the expression of 10 most robu ...[more]
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