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RNA surveillance by the nuclear RNA exosome: mechanisms and significance.

ABSTRACT: The nuclear RNA exosome is an essential and versatile machinery that regulates maturation and degradation of a huge plethora of RNA species. The past two decades have witnessed remarkable progress in understanding the whole picture of its RNA substrates and the structural basis of its functions. In addition to the exosome itself, recent studies focusing on associated co-factors have been elucidating how the exosome is directed towards specific substrates. Moreover, it has been gradually realized that loss-of-function of exosome subunits affect multiple biological processes such as the DNA damage response, R-loop resolution, maintenance of genome integrity, RNA export, translation and cell differentiation. In this review, we summarize the current knowledge of the mechanisms of nuclear exosome-mediated RNA metabolism and discuss their physiological significance.

SUBMITTER: Ogami K

PROVIDER: S-EPMC5886371 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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RNA surveillance by the nuclear RNA exosome: mechanisms and significance.

Ogami Koichi K Chen Yaqiong Y Manley James L JL

Non-coding RNA 20180311 1

The nuclear RNA exosome is an essential and versatile machinery that regulates maturation and degradation of a huge plethora of RNA species. The past two decades have witnessed remarkable progress in understanding the whole picture of its RNA substrates and the structural basis of its functions. In addition to the exosome itself, recent studies focusing on associated co-factors have been elucidating how the exosome is directed towards specific substrates. Moreover, it has been gradually realized ...[more]

PMID: 29629374

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Nuclear exosome

Project description:Nuclear exosome

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