Ontology highlight
ABSTRACT:
SUBMITTER: Chang AC
PROVIDER: S-EPMC5886374 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Chang Alice C AC Mekhdjian Armen H AH Morimatsu Masatoshi M Denisin Aleksandra Kirillovna AK Pruitt Beth L BL Dunn Alexander R AR
ACS nano 20161128 12
Integrins mediate cell adhesion to the extracellular matrix and enable the construction of complex, multicellular organisms, yet fundamental aspects of integrin-based adhesion remain poorly understood. Notably, the magnitude of the mechanical load experienced by individual integrins within living cells is unclear, due principally to limitations inherent to existing techniques. Here we use Förster resonance energy transfer-based molecular tension sensors to directly measure the distribution of lo ...[more]