Ontology highlight
ABSTRACT:
SUBMITTER: Fassnacht C
PROVIDER: S-EPMC5886687 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Fassnacht Christina C Tocchini Cristina C Kumari Pooja P Gaidatzis Dimos D Stadler Michael B MB Ciosk Rafal R
PLoS genetics 20180326 3
Endogenous RNAi (endoRNAi) is a conserved mechanism for fine-tuning gene expression. In the nematode Caenorhabditis elegans, several endoRNAi pathways are required for the successful development of reproductive cells. The CSR-1 endoRNAi pathway promotes germ cell development, primarily by facilitating the expression of germline genes. In this study, we report a novel function for the CSR-1 pathway in preventing premature activation of embryonic transcription in the developing oocytes, which is a ...[more]