Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer.
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ABSTRACT:
SUBMITTER: Mezheyeuski A
PROVIDER: S-EPMC5887004 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer.
Mezheyeuski Artur A Strell Carina C Hrynchyk Ina I Guren Tormod Kyrre TK Dragomir Anca A Doroshenko Tatyana T Pashkova Oksana O Gorgun Julia J Ruksha Kseniya K Pfeiffer Per P Kure Elin H EH Sorbye Halfdan H Edler David D Martling Anna A Glimelius Bengt B Östman Arne A Portyanko Anna A
Virchows Archiv : an international journal of pathology 20171113 3
Claudin-2 is a trans-membrane protein-component of tight junctions in epithelial cells. Elevated claudin-2 expression has been reported in colorectal cancer (CRC). The aim of this study was to investigate the expression patterns of claudin-2 in human CRC samples and analyze its association with clinical characteristics and treatment outcome. TMAs of primary tumors from two cohorts of metastatic CRC (mCRC) were used. Claudin-2 IHC staining was evaluated in a semi-quantitative manner in different ...[more]
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