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Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss.


ABSTRACT: The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history.During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study did not find any association between MTHFR C677T polymorphism and gender (p?>?0.05), gestational period (p?>?0.05), geographical region (p?>?0.05) and menstrual history (p?>?0.05). However, significant association was seen between MTHFR C677T polymorphism and number of losses (p?

SUBMITTER: Sah AK 

PROVIDER: S-EPMC5887178 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss.

Sah Anil Kumar AK   Shrestha Nisha N   Joshi Pratikshya P   Lakha Renu R   Shrestha Sweta S   Sharma Laxmi L   Chandra Avinash A   Singh Neetu N   Kc Yuvraj Y   Rijal Bhola B  

BMC research notes 20180405 1


<h4>Objective</h4>The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history.<h4>Results</h4>During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study did not find any association between MTHFR C677T polymorphism and gender (p > 0.05), gestational period (p > 0.05), geographical region (p > 0.05) and menstrual history  ...[more]

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