Ontology highlight
ABSTRACT:
SUBMITTER: Mersaoui SY
PROVIDER: S-EPMC5887288 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Mersaoui Sofiane Y SY Bonnell Erin E Wellinger Raymund J RJ
Nucleic acids research 20180401 6
Cdc13 is an essential protein involved in telomere maintenance and chromosome capping. Individual domain analyses on Cdc13 suggest the presence of four distinct OB-fold domains and one recruitment domain. However, it remained unclear how these sub-domains function in the context of the whole protein in vivo. Here, we use individual single domain deletions to address their roles in telomere capping. We find that the OB2 domain contains a nuclear localization signal that is essential for nuclear i ...[more]