Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC5887438 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wu Xiaoxian X Haakonsen Diane L DL Sanderlin Allen G AG Liu Yue J YJ Shen Liqiang L Zhuang Ningning N Laub Michael T MT Zhang Yu Y
Nucleic acids research 20180401 6
Canonical bacterial transcription activators bind to non-transcribed promoter elements to increase transcription of their target genes. Here we report crystal structures of binary complexes comprising domains of Caulobacter crescentus GcrA, a noncanonical bacterial transcription factor, that support a novel mechanism for transcription activation through the preferential binding of methylated cis-regulatory elements and the promotion of open complex formation through an interaction with region 2 ...[more]