WeSME: uncovering mutual exclusivity of cancer drivers and beyond.

ABSTRACT:

Motivation

Mutual exclusivity is a widely recognized property of many cancer drivers. Knowledge about these relationships can provide important insights into cancer drivers, cancer-driving pathways and cancer subtypes. It can also be used to predict new functional interactions between cancer driving genes and uncover novel cancer drivers. Currently, most of mutual exclusivity analyses are preformed focusing on a limited set of genes in part due to the computational cost required to rigorously compute P -values.

Results

To reduce the computing cost and perform less restricted mutual exclusivity analysis, we developed an efficient method to estimate P -values while controlling the mutation rates of individual patients and genes similar to the permutation test. A comprehensive

SUBMITTER: Kim YA 

PROVIDER: S-EPMC5888950 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature