Prognostic markers for colorectal cancer: estimating ploidy and stroma.
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ABSTRACT:
SUBMITTER: Danielsen HE
PROVIDER: S-EPMC5889021 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Prognostic markers for colorectal cancer: estimating ploidy and stroma.
Danielsen H E HE Hveem T S TS Domingo E E Pradhan M M Kleppe A A Syvertsen R A RA Kostolomov I I Nesheim J A JA Askautrud H A HA Nesbakken A A Lothe R A RA Svindland A A Shepherd N N Novelli M M Johnstone E E Tomlinson I I Kerr R R Kerr D J DJ
Annals of oncology : official journal of the European Society for Medical Oncology 20180301 3
<h4>Background</h4>We report here the prognostic value of ploidy and digital tumour-stromal morphometric analyses using material from 2624 patients with early stage colorectal cancer (CRC).<h4>Patients and methods</h4>DNA content (ploidy) and stroma-tumour fraction were estimated using automated digital imaging systems and DNA was extracted from sections of formalin-fixed paraffin-embedded (FFPE) tissue for analysis of microsatellite instability. Samples were available from 1092 patients recruit ...[more]
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| S-EPMC9830322 | biostudies-literature