Ontology highlight
ABSTRACT:
SUBMITTER: Bahrami-Nejad Z
PROVIDER: S-EPMC5889123 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Bahrami-Nejad Zahra Z Zhao Michael L ML Tholen Stefan S Hunerdosse Devon D Tkach Karen E KE van Schie Sabine S Chung Mingyu M Teruel Mary N MN
Cell metabolism 20180401 4
Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising the intriguing question of how hormone secretion dynamics affect adipocyte differentiation. Using live, single-cell imaging of the key adipogenic transcription factors CEBPB and PPARG, endogenously tagged with fluorescent proteins, we show that pulsatile circadian hormone stimuli are rejected by the adipocyte differe ...[more]