Ontology highlight
ABSTRACT:
SUBMITTER: Teulings HE
PROVIDER: S-EPMC5889200 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Teulings Hansje-Eva HE Tjin Esther P M EPM Willemsen Karina J KJ van der Kleij Stephanie S Ter Meulen Sylvia S Kemp E Helen EH Krebbers Gabrielle G van Noesel Carel J M CJM Franken Cornelis L M C CLMC Drijfhout Jan W JW Melief Cornelis J M CJM Nieuweboer-Krobotova Ludmila L Nieweg Omgo E OE van der Hage Jos A JA van der Veen J P Wietze JPW Relyveld Germaine N GN Luiten Rosalie M RM
Oncoimmunology 20180115 4
Vitiligo development in melanoma patients during immunotherapy is a favorable prognostic sign and indicates breakage of tolerance against melanocytic/melanoma antigens. We investigated a novel immunotherapeutic approach of the skin-depigmenting compound monobenzone synergizing with imiquimod in inducing antimelanoma immunity and melanoma regression. Stage III-IV melanoma patients with non-resectable cutaneous melanoma metastases were treated with monobenzone and imiquimod (MI) therapy applied lo ...[more]