Ontology highlight
ABSTRACT:
SUBMITTER: Siddam AD
PROVIDER: S-EPMC5889275 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Siddam Archana D AD Gautier-Courteille Carole C Perez-Campos Linette L Anand Deepti D Kakrana Atul A Dang Christine A CA Legagneux Vincent V Méreau Agnès A Viet Justine J Gross Jeffrey M JM Paillard Luc L Lachke Salil A SA
PLoS genetics 20180322 3
Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a fundamental question: does signaling/transcription sufficiently explain differentiation of cells progressing toward compromised transcriptional potential? We report that a conserved RNA-binding protein Celf1 post-transcriptionally controls key genes to regulate lens fiber cell differentiation. Celf ...[more]