Ontology highlight
ABSTRACT:
SUBMITTER: Du S
PROVIDER: S-EPMC5889288 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Oncoimmunology 20180129 4
Anti-PD-1 immunotherapy is the standard of care for treating many patients with non-small cell lung cancer (NSCLC), yet mechanisms of treatment failure are emerging. We present a case of NSCLC, who rapidly progressed during a trial (NCT02318771) combining palliative radiotherapy and pembrolizumab. Planned tumor biopsy demonstrated PD-1 expression by NSCLC cells. We validated this observation by detecting PD-1 transcript in lung cancer cells and by co-localizing PD-1 and lung cancer-specific mark ...[more]