Ontology highlight
ABSTRACT:
SUBMITTER: Liu N
PROVIDER: S-EPMC5889339 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Liu Nan N Hargreaves Victoria V VV Zhu Qian Q Kurland Jesse V JV Hong Jiyoung J Kim Woojin W Sher Falak F Macias-Trevino Claudio C Rogers Julia M JM Kurita Ryo R Nakamura Yukio Y Yuan Guo-Cheng GC Bauer Daniel E DE Xu Jian J Bulyk Martha L ML Orkin Stuart H SH
Cell 20180329 2
Fetal hemoglobin (HbF, α<sub>2</sub>γ<sub>2</sub>) level is genetically controlled and modifies severity of adult hemoglobin (HbA, α<sub>2</sub>β<sub>2</sub>) disorders, sickle cell disease, and β-thalassemia. Common genetic variation affects expression of BCL11A, a regulator of HbF silencing. To uncover how BCL11A supports the developmental switch from γ- to β- globin, we use a functional assay and protein binding microarray to establish a requirement for a zinc-finger cluster in BCL11A in repr ...[more]