Ontology highlight
ABSTRACT:
SUBMITTER: Bilokapic S
PROVIDER: S-EPMC5889399 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Bilokapic Silvija S Strauss Mike M Halic Mario M
Nature communications 20180406 1
Nucleosomes, the basic unit of chromatin, package and regulate expression of eukaryotic genomes. Nucleosomes are highly dynamic and are remodeled with the help of ATP-dependent remodeling factors. Yet, the mechanism of DNA translocation around the histone octamer is poorly understood. In this study, we present several nucleosome structures showing histone proteins and DNA in different organizational states. We observe that the histone octamer undergoes conformational changes that distort the ove ...[more]