Dataset Information

The Brain Health Assessment for Detecting and Diagnosing Neurocognitive Disorders.

ABSTRACT: BACKGROUND/OBJECTIVES:Brief cognitive screens lack the sensitivity to detect mild cognitive impairment (MCI) or support differential diagnoses. The objective of this study was to validate the 10-minute, tablet-based University of California, San Francisco (UCSF) Brain Health Assessment (BHA) to overcome these limitations. DESIGN:Cross-sectional. SETTING:UCSF Memory and Aging Center. PARTICIPANTS:Older adults (N = 347) (neurologically healthy controls (n = 185), and individuals diagnosed with MCI (n = 99), dementia (n = 42), and as normal with concerns (n = 21)). MEASUREMENTS:The BHA includes subtests of memory, executive function and speed, visuospatial skills, and language and an optional informant survey. Participants completed the Montreal Cognitive Assessment (MoCA) and criterion-standard neuropsychological tests. Standardized structural 3T brain magnetic resonance imaging was performed in 145 participants. RESULTS:At a fixed 85% specificity rate, the BHA had 100% sensitivity to dementia and 84% to MCI; the MoCA had 75% sensitivity to dementia and 25% to MCI. The BHA had 83% sensitivity to MCI likely due to AD and 88% to MCI unlikely due to AD, and the MoCA had 58% sensitivity to MCI likely AD and 24% to MCI unlikely AD. The BHA subtests demonstrated moderate to high correlations with the criterion-standard tests from their respective cognitive domains. Memory test performance correlated with medial temporal lobe volumes; executive and speed with frontal, parietal, and basal ganglia volumes; and visuospatial with right parietal volumes. CONCLUSION:The BHA had excellent combined sensitivity and specificity to detect dementia and MCI, including MCI due to diverse etiologies. The subtests provide efficient, valid measures of neurocognition that are critical in making a differential diagnosis.

SUBMITTER: Possin KL

PROVIDER: S-EPMC5889617 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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The Brain Health Assessment for Detecting and Diagnosing Neurocognitive Disorders.

Possin Katherine L KL Moskowitz Tacie T Erlhoff Sabrina J SJ Rogers Kirsten M KM Johnson Erica T ET Steele Natasha Z R NZR Higgins Joseph J JJ Stiver Jordan J Alioto Andrea G AG Farias Sarah T ST Miller Bruce L BL Rankin Katherine P KP

Journal of the American Geriatrics Society 20180101 1

<h4>Background/objectives</h4>Brief cognitive screens lack the sensitivity to detect mild cognitive impairment (MCI) or support differential diagnoses. The objective of this study was to validate the 10-minute, tablet-based University of California, San Francisco (UCSF) Brain Health Assessment (BHA) to overcome these limitations.<h4>Design</h4>Cross-sectional.<h4>Setting</h4>UCSF Memory and Aging Center.<h4>Participants</h4>Older adults (N = 347) (neurologically healthy controls (n = 185), and i ...[more]

PMID: 29355911

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Dataset Information

The Brain Health Assessment for Detecting and Diagnosing Neurocognitive Disorders.

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The Brain Health Assessment for Detecting and Diagnosing Neurocognitive Disorders.

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