Ontology highlight
ABSTRACT:
SUBMITTER: Silva-Platas C
PROVIDER: S-EPMC5889877 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Silva-Platas Christian C Villegas César A CA Oropeza-Almazán Yuriana Y Carrancá Mariana M Torres-Quintanilla Alejandro A Lozano Omar O Valero-Elizondo Javier J Castillo Elena C EC Bernal-Ramírez Judith J Fernández-Sada Evaristo E Vega Luis F LF Treviño-Saldaña Niria N Chapoy-Villanueva Héctor H Ruiz-Azuara Lena L Hernández-Brenes Carmen C Elizondo-Montemayor Leticia L Guerrero-Beltrán Carlos E CE Carvajal Karla K Bravo-Gómez María E ME García-Rivas Gerardo G
Oxidative medicine and cellular longevity 20180325
Casiopeinas are a group of copper-based antineoplastic molecules designed as a less toxic and more therapeutic alternative to cisplatin or Doxorubicin; however, there is scarce evidence about their toxic effects on the whole heart and cardiomyocytes. Given this, rat hearts were perfused with Casiopeinas or Doxorubicin and the effects on mechanical performance, energetics, and mitochondrial function were measured. As well, the effects of Casiopeinas-triggered cell death were explored in isolated ...[more]