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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

ABSTRACT: Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.

SUBMITTER: Vijayakrishnan J 

PROVIDER: S-EPMC5890276 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

Vijayakrishnan Jayaram J   Studd James J   Broderick Peter P   Kinnersley Ben B   Holroyd Amy A   Law Philip J PJ   Kumar Rajiv R   Allan James M JM   Harrison Christine J CJ   Moorman Anthony V AV   Vora Ajay A   Roman Eve E   Rachakonda Sivaramakrishna S   Kinsey Sally E SE   Sheridan Eamonn E   Thompson Pamela D PD   Irving Julie A JA   Koehler Rolf R   Hoffmann Per P   Nöthen Markus M MM   Heilmann-Heimbach Stefanie S   Jöckel Karl-Heinz KH   Easton Douglas F DF   Pharaoh Paul D P PDP   Dunning Alison M AM   Peto Julian J   Canzian Frederico F   Swerdlow Anthony A   Eeles Rosalind A RA   Kote-Jarai ZSofia Z   Muir Kenneth K   Pashayan Nora N   Greaves Mel M   Zimmerman Martin M   Bartram Claus R CR   Schrappe Martin M   Stanulla Martin M   Hemminki Kari K   Houlston Richard S RS  

Nature communications 20180409 1

Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10<sup>-9</sup>, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869,  ...[more]

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