Defects in Bioenergetic Coupling in Schizophrenia.
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ABSTRACT:
SUBMITTER: Sullivan CR
PROVIDER: S-EPMC5891385 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Defects in Bioenergetic Coupling in Schizophrenia.
Sullivan Courtney R CR O'Donovan Sinead M SM McCullumsmith Robert E RE Ramsey Amy A
Biological psychiatry 20171024 9
Synaptic neurotransmission relies on maintenance of the synapse and meeting the energy demands of neurons. Defects in excitatory and inhibitory synapses have been implicated in schizophrenia, likely contributing to positive and negative symptoms as well as impaired cognition. Recently, accumulating evidence has suggested that bioenergetic systems, important in both synaptic function and cognition, are abnormal in psychiatric illnesses such as schizophrenia. Animal models of synaptic dysfunction ...[more]
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