Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimura T
PROVIDER: S-EPMC5891400 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Yoshimura Takuji T Watanabe Toshiaki T Kuramochi-Miyagawa Satomi S Takemoto Noriaki N Shiromoto Yusuke Y Kudo Akihiko A Kanai-Azuma Masami M Tashiro Fumi F Miyazaki Satsuki S Katanaya Ami A Chuma Shinichiro S Miyazaki Jun-Ichi JI
EMBO reports 20180207 4
The piRNA pathway is a piRNA-guided retrotransposon silencing system which includes processing of retrotransposon transcripts by PIWI-piRNAs in secondary piRNA biogenesis. Although several proteins participate in the piRNA pathway, the ones crucial for the cleavage of target RNAs by PIWI-piRNAs have not been identified. Here, we show that GTSF1, an essential factor for retrotransposon silencing in male germ cells in mice, associates with both MILI and MIWI2, mouse PIWI proteins that function in ...[more]