Cerebral rituximab uptake in multiple sclerosis: A 89Zr-immunoPET pilot study.
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ABSTRACT:
SUBMITTER: Hagens MH
PROVIDER: S-EPMC5891689 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Cerebral rituximab uptake in multiple sclerosis: A <sup>89</sup>Zr-immunoPET pilot study.
Hagens Marloes Hj MH Killestein Joep J Yaqub Maqsood M MM van Dongen Guus Ams GA Lammertsma Adriaan A AA Barkhof Frederik F van Berckel Bart Nm BN
Multiple sclerosis (Houndmills, Basingstoke, England) 20170426 4
Previous studies have demonstrated that the chimeric monoclonal antibody rituximab significantly reduces clinical and radiological disease activity in relapsing-remitting multiple sclerosis as early as 4 weeks after the first administration. The exact mechanisms leading to this rapid effect have not yet been clarified. The aim of this positron emission tomography study was to assess central nervous system penetration as a possible explanation, using zirconium-89-labelled rituximab. No evidence w ...[more]
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