Shared facial emotion processing functional network findings in medication-naive major depressive disorder and healthy individuals: detection by sICA.

ABSTRACT: BACKGROUND:The fundamental mechanism underlying emotional processing in major depressive disorder (MDD) remains unclear. To better understand the neural correlates of emotional processing in MDD, we investigated the role of multiple functional networks (FNs) during emotional stimuli processing. METHODS:Thirty-two medication-naïve subjects with MDD and 36 healthy controls (HCs) underwent an emotional faces fMRI task that included neutral, happy and fearful expressions. Spatial independent component analysis (sICA) and general linear model (GLM) were conducted to examine the main effect of task condition and group, and two-way interactions of group and task conditions. RESULTS:In sICA analysis, MDD patients and HCs together showed significant differences in task-related modulations in five F

SUBMITTER: Li J 

PROVIDER: S-EPMC5891939 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature