Principles and methods of in-silico prioritization of non-coding regulatory variants.
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ABSTRACT:
SUBMITTER: Lee PH
PROVIDER: S-EPMC5892192 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Principles and methods of in-silico prioritization of non-coding regulatory variants.
Lee Phil H PH Lee Christian C Li Xihao X Wee Brian B Dwivedi Tushar T Daly Mark M
Human genetics 20171229 1
Over a decade of genome-wide association, studies have made great strides toward the detection of genes and genetic mechanisms underlying complex traits. However, the majority of associated loci reside in non-coding regions that are functionally uncharacterized in general. Now, the availability of large-scale tissue and cell type-specific transcriptome and epigenome data enables us to elucidate how non-coding genetic variants can affect gene expressions and are associated with phenotypic changes ...[more]
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