Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC5892590 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Zhu Xiaoliang X Yuan Chunmao C Tian Chenyang C Li Chen C Nie Fen F Song Xiaomin X Zeng Rong R Wu Dianqing D Hao Xiaojiang X Li Lin L
The Journal of biological chemistry 20180209 14
The Wnt/β-catenin pathway is essential for embryonic development and homeostasis, but excessive activation of this pathway is frequently observed in various human diseases, including cancer. Current therapeutic drugs targeting the Wnt pathway often lack sufficient efficacy, and new compounds targeting this pathway are therefore greatly needed. Here we report that the plant-derived natural product parthenolide (PTL), a sesquiterpene lactone, inhibits Wnt signaling. We found that PTL dose-dependen ...[more]