Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC5892726 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20180103 3
Establishment of an in vivo small animal model of human tumor and human immune system interaction would enable preclinical investigations into the mechanisms underlying cancer immunotherapy. To this end, nonobese diabetic (NOD).Cg- Prkdc<sup>scid</sup>IL2rg<sup>tm1Wjl</sup>/Sz (null; NSG) mice were transplanted with human (h)CD34<sup>+</sup> hematopoietic progenitor and stem cells, which leads to the development of human hematopoietic and immune systems [humanized NSG (HuNSG)]. HuNSG mice receiv ...[more]