Ontology highlight
ABSTRACT:
SUBMITTER: Wang YN
PROVIDER: S-EPMC5893359 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wang Ying-Nai YN Lee Heng-Huan HH Chou Chao-Kai CK Yang Wen-Hao WH Wei Yongkun Y Chen Chun-Te CT Yao Jun J Hsu Jennifer L JL Zhu Cihui C Ying Haoqiang H Ye Yuanqing Y Wang Wei-Jan WJ Lim Seung-Oe SO Xia Weiya W Ko How-Wen HW Liu Xiuping X Liu Chang-Gong CG Wu Xifeng X Wang Huamin H Li Donghui D Prakash Laura R LR Katz Matthew H MH Kang Yaan Y Kim Michael M Fleming Jason B JB Fogelman David D Javle Milind M Maitra Anirban A Hung Mien-Chie MC
Cancer cell 20180329 4
Pancreatic ribonuclease (RNase) is a secreted enzyme critical for host defense. We discover an intrinsic RNase function, serving as a ligand for epidermal growth factor receptor (EGFR), a member of receptor tyrosine kinase (RTK), in pancreatic ductal adenocarcinoma (PDAC). The closely related bovine RNase A and human RNase 5 (angiogenin [ANG]) can trigger oncogenic transformation independently of their catalytic activities via direct association with EGFR. Notably, high plasma ANG level in PDAC ...[more]