Ontology highlight
ABSTRACT:
SUBMITTER: Dixon KO
PROVIDER: S-EPMC5893394 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Dixon Karen O KO Schorer Michelle M Nevin James J Etminan Yassaman Y Amoozgar Zohreh Z Kondo Takaaki T Kurtulus Sema S Kassam Nasim N Sobel Raymond A RA Fukumura Dai D Jain Rakesh K RK Anderson Ana C AC Kuchroo Vijay K VK Joller Nicole N
Journal of immunology (Baltimore, Md. : 1950) 20180302 8
Coinhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have gained attention as therapeutic targets in chronic disease settings where their dysregulated expression contributes to suppressed immune responses. The novel coinhibitory receptor TIGIT (T cell Ig and ITIM domain) has been shown to play an important role in modulating immune responses in the context of autoimmunity and cancer. However, the mol ...[more]