Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.
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ABSTRACT:
SUBMITTER: Folgueras AR
PROVIDER: S-EPMC5893555 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.
Folgueras Alicia R AR Freitas-Rodríguez Sandra S Ramsay Andrew J AJ Garabaya Cecilia C Rodríguez Francisco F Velasco Gloria G López-Otín Carlos C
Nature communications 20180410 1
Alterations in iron status have frequently been associated with obesity and other metabolic disorders. The hormone hepcidin stands out as a key regulator in the maintenance of iron homeostasis by controlling the main iron exporter, ferroportin. Here we demonstrate that the deficiency in the hepcidin repressor matriptase-2 (Tmprss6) protects from high-fat diet-induced obesity. Tmprss6 <sup>-/-</sup> mice show a significant decrease in body fat, improved glucose tolerance and insulin sensitivity, ...[more]
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