Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC5893556 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Zhang Zhenjing Z Shen Wanwan W Ling Jing J Yan Yang Y Hu Jingjing J Cheng Yiyun Y
Nature communications 20180410 1
Direct delivery of proteins into cells avoids many drawbacks of gene delivery, and thus has emerging applications in biotherapy. However, it remains a challenging task owing to limited charges and relatively large size of proteins. Here, we report an efficient protein delivery system via the co-assembly of fluoroamphiphiles and proteins into nanoparticles. Fluorous substituents on the amphiphiles play essential roles in the formation of uniform nanoparticles, avoiding protein denaturation, effic ...[more]