Ontology highlight
ABSTRACT:
SUBMITTER: Joas S
PROVIDER: S-EPMC5893559 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature communications 20180410 1
HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i.e., a Vpu protein that antagonizes tetherin and blocks NF-κB activation and a Nef protein that fails to suppress T cell activation via ...[more]