Ontology highlight
ABSTRACT:
SUBMITTER: Dautant A
PROVIDER: S-EPMC5893901 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Dautant Alain A Meier Thomas T Hahn Alexander A Tribouillard-Tanvier Déborah D di Rago Jean-Paul JP Kucharczyk Roza R
Frontiers in physiology 20180404
Devastating human neuromuscular disorders have been associated to defects in the ATP synthase. This enzyme is found in the inner mitochondrial membrane and catalyzes the last step in oxidative phosphorylation, which provides aerobic eukaryotes with ATP. With the advent of structures of complete ATP synthases, and the availability of genetically approachable systems such as the yeast <i>Saccharomyces cerevisiae</i>, we can begin to understand these molecular machines and their associated defects ...[more]